|
KMID : 0360319930250040501
|
|
Journal of Korean Cancer Research Association
1993 Volume.25 No. 4 p.501 ~ p.506
|
|
|
Significance of Chromogranin-A Expression in the Bile Duct Cancer
|
|
|
|
|
Abstract
|
|
|
To investigate whether neuroendocrine differentiation exists and has any clinical significance in cancers of the common bile duct, paraffin sections of samples from 37 cases of these tumors resected from 1986 to 1990 were immunostained for
chromogranin-A(CgA). Thirteen tumors(35%) had tumor cells stained with CgA. Although the patients with CgA positive tumors were rather younger, no other difference was noted between CgA negative group and CgA positive group in clinico-pathologic
characteristics including sex, extent of disease, histologic and gross types, location of tumor. The patients were analysed for survival time according to the extent of disease and CgA positivity. Prognosis of CgA positive tumor was significantly
worse
than that of CgA negative tumor in the cases without lymph node metastasis or adjacent organ invasion. This study suggests that the incidence of neuroendocrine differentiation is rather high and neuroendocrine differentiation is associated with
poor
prognosis in cancers of the common bile duct.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|